Search Result

Search Results for " i factor "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
TP1122L	IGF-I 30-41 acetate(82177-09-1 free base)	Insulin-like Growth Factor I (30-41) acetate	Others
	IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).		Others
T80059	Complement factor I		Endogenous Metabolite
	Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein...		Endogenous Metabolite
T4026	SU5408	VEGFR2 Kinase Inhibitor I	VEGFR
	SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.		VEGFR
T4191	Multi-kinase inhibitor 1	Multi-kinase inhibitor I	Others , Bcr-Abl , PDGFR , c-Kit
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.		Others , Bcr-Abl , PDGFR , c-Kit
TD0099	Malachite green oxalate		Apoptosis , Others , IκB/IKK , NF-κB
	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.		Apoptosis , Others , IκB/IKK , NF-κB
T0708	Oxaprozin	Oxaprozinum,Wy21743	NF-κB , COX
	Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...		NF-κB , COX
TP1122	IGF-I (30-41)	Insulin-like Growth Factor I (30-41),IGF-I 30-41
	IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
TP1124	IGF-I (24-41)	Insulin-like Growth Factor I (24-41),IGF-I 24-41
	IGF-I (24-41) is a 24-41 amino acid fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, a...
TP1121	IGF-I (30-41) TFA(82177-09-1,FREE)	Insulin-like Growth Factor I (30-41) (TFA)
	IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
TP1123	IGF-I (24-41) TFA (135861-49-3 free base)	Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA
	IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).IGF-I (24-41) (TFA) is amino acids 24 to ...
T1944	LDN-214117		ALK , TGF-beta/Smad
	LDN-214117 is a potent and selective ALK2 inhibitor.		ALK , TGF-beta/Smad
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T1083L	Theophylline monohydrate	Quibron	HDAC , PDE , Adenosine Receptor
	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...		HDAC , PDE , Adenosine Receptor
TP1021	Urocortin, human	Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I	CRFR
	Urocortin, human (Human urocortin I) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).		CRFR
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T16708	R-268712		ALK , TGF-beta/Smad
	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.		ALK , TGF-beta/Smad
T13613	ChX710		STING
	ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory ...		STING
T9088	Topovale	ARC111,ARC 111,ARC-111,Topoval	Topoisomerase
	Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topo...		Topoisomerase
T62483	CJJ300		TGF-beta/Smad
	CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration.		TGF-beta/Smad
T2368L	Edoxaban	Lixiana	Factor Xa , Thrombin
	Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a...		Factor Xa , Thrombin
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
T4027	KIN1148		Influenza Virus
	KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an ...		Influenza Virus
T70568	H-1356
	H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.
T69212	LY-580276
	LY-580276 is an inhibitor of the type I transforming growth factor beta receptor (TβRI).
T27224	DX-9065A HCl hydrate	DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase ...
T68333	Galunisertib Monohydrate
	Galunisertib Monohydrate is a first-in-class transforming growth factor-β receptor type I inhibitor.
T79124	JGK-068S		EGFR
	Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].		EGFR
T29493	A 17002 C	A-17002 C,A17002 C,A17002C,A 17002C,A-17002C
	A 17002 C is a form of madumycin I. It is a metabolite produced by Actinoplanes strains, structurally related to the virginiamycin factor M.
T27698	JTV-803 mesylate	JTV803,JTV 803,JTV-803
	JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting ...
T62597	TEAD-IN-3
	TEAD-IN-3 (compound I-177) is a potent inhibitor of the TEAD transcription factor, which can be used to study proliferative diseases such as cancer.
T73702	Mecasermin
	Mecasermin (Human IGF-I; FK 780), a recombinant form of human insulin-like growth factor I (IGF-I), holds promise for investigating growth failure attributed to growth hormone (GH) insensitivity, which may be due to defe...
TP1361	S961 TFA (1083433-49-1 free base)	S961 TFA
	S961 TFA is A high affinity insulin receptor (IR) antagonist with IC50 for hir-a, hir-b and human insulin-like growth factor I receptor (higf-ir) at 0.048, 0.027 and 630 nM, respectively.
T76012	IGF-I (30-41) (TFA)
	IGF-I (30-41) (TFA) is a fragment consisting of amino acids 30 to 41 from Insulin-like Growth Factor I (IGF-I), a compound responsible in part for systemic GH (Growth Hormone) activities. It exhibits an array of properti...
T39223	Milvexian	JNJ-70033093,BMS-986177
	Milvexian (BMS-986177) is a potent antithrombotic compound that inhibits human and rabbit factor XIa (FXIa) directly and reversibly. It is orally-bioavailable and exhibits a K i of 0.11 nM and 0.38 nM against human and r...
T76014	IGF-I (24-41) (TFA)
	Insulin-like Growth Factor I (24-41) TFA, a fragment comprising amino acids 24 to 41 of the full IGF-I TFA molecule, is a variant of IGF-I TFA, which itself is a 70 amino acid polypeptide hormone. This hormone serves as ...
T61506	NBI-31772 hydrate
	NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-...
T39029	APC-6860
	APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA ve...
T82361	FXIIa-IN-1
	XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].
T82360	FXIIa-IN-2
	XIIa-IN-1-IN-2 (Compound 21) serves as a potent Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 62.2 nM, utilized primarily in thrombosis research [1].
T76043	S961 TFA
	S961 TFA is a highly selective and high-affinity antagonist of the insulin receptor (IR), demonstrating IC50 values of 0.048 nM for HIR-A, 0.027 nM for HIR-B, and 630 nM for the human insulin-like growth factor I recepto...
TP1795	S961
	S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048,0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in scintillation proximity assay, ...
T77221	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)
	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptas...
T76043L	S961 acetate
	S961 acetate is a selective and high-affinity antagonist of the insulin receptor (IR), demonstrating IC50 values of 0.048 nM for HIR-A, 0.027 nM for HIR-B, and 630 nM for the human insulin-like growth factor I receptor (...
T38329	CU-76
	CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sens...
T63070	EGFR-IN-45
	EGFR-IN-45 is a potent pan-inhibitor of the epidermal growth factor receptor (EGFR), acting on EGFR (IC50: 0.4 μM) and CDK2 (IC50: 1.6 μM). EGFR-IN-45 also inhibits the topoisomerases Topo I and Topo II. EGFR-IN-45 block...
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II...
T77038	Interferon alfa
	Interferon alfa, a type I interferon, activates new genes, displaying strong antiviral and antiproliferative effects on target cells. It signals through receptor-mediated activation of Stat1 and Stat2, which heterodimeri...
T38328	CU-32
	CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS ...
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune diso...

Compounds

IGF-I 30-41 acetate(82177-09-1 free base)

TP1122L

Synonym: Insulin-like Growth Factor I (30-41) acetate

Target: Others

Complement factor I

T80059

Synonym:

Target: Endogenous Metabolite

SU5408

T4026

Synonym: VEGFR2 Kinase Inhibitor I

Target: VEGFR

Multi-kinase inhibitor 1

T4191

Synonym: Multi-kinase inhibitor I

Target: Others, Bcr-Abl, PDGFR, c-Kit

Malachite green oxalate

TD0099

Synonym:

Target: Apoptosis, Others, IκB/IKK, NF-κB

Oxaprozin

T0708

Synonym: Oxaprozinum,Wy21743

Target: NF-κB, COX

IGF-I (30-41)

TP1122

Synonym: Insulin-like Growth Factor I (30-41),IGF-I 30-41

Target:

IGF-I (24-41)

TP1124

Synonym: Insulin-like Growth Factor I (24-41),IGF-I 24-41

Target:

IGF-I (30-41) TFA(82177-09-1,FREE)

TP1121

Synonym: Insulin-like Growth Factor I (30-41) (TFA)

Target:

IGF-I (24-41) TFA (135861-49-3 free base)

TP1123

Synonym: Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA

Target: ALK, TGF-beta/Smad

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Theophylline monohydrate

T1083L

Synonym: Quibron

Target: HDAC, PDE, Adenosine Receptor

Urocortin, human

TP1021

Synonym: Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I

Target: CRFR

Suramin Sodium Salt

T2160

Synonym: BAY-205,Suramin hexasodium salt,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

R-268712

T16708

Synonym:

Target: ALK, TGF-beta/Smad

Synonym: ARC111,ARC 111,ARC-111,Topoval

Target: Topoisomerase

CJJ300

T62483

Synonym:

Target: TGF-beta/Smad

Edoxaban

T2368L

Synonym: Lixiana

Target: Factor Xa, Thrombin

Metarrestin

T12006

Synonym: ML246

Target: DNA/RNA Synthesis

KIN1148

T4027

Synonym:

Target: Influenza Virus

Synonym: DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065

Target:

Galunisertib Monohydrate

Synonym: A-17002 C,A17002 C,A17002C,A 17002C,A-17002C

Target:

JTV-803 mesylate

T27698

Synonym: JTV803,JTV 803,JTV-803

S961 TFA (1083433-49-1 free base)

Synonym: JNJ-70033093,BMS-986177

Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)

Urocortin II (mouse) (trifluoroacetate salt)

Cat No.	Product Name	Synonyms	Targets
T2801	Aristolochic acid A	TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid	Others , NF-κB
	Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants.		Others , NF-κB
T5S0089	Kaempferol-3-O-glucorhamnoside	Kaempferol 3-glucorhamnoside	Antioxidant , p38 MAPK , NF-κB
	Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo[1]. Kaempferol-3-O-gl...		Antioxidant , p38 MAPK , NF-κB
T2873	Ginsenoside Rg2	Chikusetsusaponin I,Panaxoside Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2	Beta Amyloid , GSK-3 , NF-κB
	Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.		Beta Amyloid , GSK-3 , NF-κB
T6856	Halofuginone	Tempostatin,empostatin,RU-19110	Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
TWA2417	Sodium taurocholate	Taurocholate Sodium	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and...		Others
T10233	Acetylarenobufagin		HIF
	Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.		HIF
T2787	Picroside I	6'-Cinnamoylcatalpol	MMP , STAT
	Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ...		MMP , STAT
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
TN2217	Sophoflavescenol		Others , Beta-Secretase , BACE , PDE , AChR , AChE
	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...		Others , Beta-Secretase , BACE , PDE , AChR , AChE

Natural Products

Aristolochic acid A

T2801

Synonym: TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid

Target: Others, NF-κB

Kaempferol-3-O-glucorhamnoside

T5S0089

Synonym: Kaempferol 3-glucorhamnoside

Target: Antioxidant, p38 MAPK, NF-κB

Ginsenoside Rg2

T2873

Synonym: Chikusetsusaponin I,Panaxoside Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2

Target: Beta Amyloid, GSK-3, NF-κB

Halofuginone

T6856

Synonym: Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Halofuginone hydrobromide

T3524

Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Sodium taurocholate

TWA2417

Synonym: Taurocholate Sodium

Synonym: 6'-Cinnamoylcatalpol

Target: MMP, STAT

Parthenolide

T2140

Synonym: (-)-Parthenolide

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Yangambin

TN2322

Synonym:

Target: Calcium Channel, PAFR

Sophoflavescenol

TN2217

Synonym:

Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-01023	Complement factor I Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I P...
TMPK-00776	Complement factor I Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I P...
TMPH-03273	Complement factor I Protein, Rat, Recombinant (His & Myc)	Rat	Baculovirus Insect Cells
	Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q9WUW3.
TMPY-06982	IGF1/IGF-I Protein, Human, Recombinant	Human	E. coli
	IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1.
TMPY-04878	IGF1/IGF-I Protein, Mouse, Recombinant	Mouse	P. pastoris (Yeast)
	IGF1/IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.
TMPY-00834	IGF1R/CD221 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
TMPY-02535	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPY-01459	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
TMPH-01306	EIF4A1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str...
TMPJ-00781	LR3-IGF-1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-termin...
TMPJ-00280	TNF R1 Protein, Mouse, Recombinant	Mouse	E. coli
	Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate t...
TMPY-04942	IGF1 LR3 Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.
TMPJ-00020	IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cel...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His)	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip...
TMPY-04360	IGF1R/CD221 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
TMPY-06905	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 106.14 kDa and the accession number is NP_000866.1.
TMPH-03288	EIF3I Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ...
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ...
TMPY-04366	ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)	Human	Baculovirus Insect Cells
	ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.6 kDa and the accession number is P36897-1.
TMPY-05771	ALK-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
TMPY-01358	ALK-5 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.
TMPY-01639	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPY-05475	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1.
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPY-01009	TGFBI Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ...
TMPY-02185	Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ...
TMPJ-00994	LTBR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including ce...
TMPK-00083	IGF1/IGF-I Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I)...
TMPK-00570	CD46 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in prev...
TMPH-01798	Nucleolar transcription factor 1 Protein, Human, Recombinant (Cell-Free, His & SUMO)	Human	E. coli
	Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream...
TMPK-00428	HER2/ErbB2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t...
TMPH-01799	Nucleolar transcription factor 1 Protein, Human, Recombinant (E. coli, His & SUMO)	Human	E. coli
	Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream...
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPK-01027	IGFBP-7 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ...
TMPJ-00123	FLT3LG Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and...
TMPK-00532	CD46 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in prev...
TMPJ-00274	LTBR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,...
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ...
TMPJ-00973	EIF1AX Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic Translation Initiation Factor 1A, X-Chromosomal (EIF1AX) is an essential eukaryotic translation initiation factor that belongs to the eIF-1A family. EIF1AX is required for the binding of the 43S complex (a 40S...
TMPJ-00572	Vasorin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair af...
TMPH-02606	CR1L Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor,...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His)	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NF...
TMPY-03329	DPEP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...
TMPJ-00315	ACVR2A Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation fact...
TMPJ-00314	ACVR2B Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors...
TMPJ-00535	F13A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, ...
TMPU-00003	STAT2 Protein, Human, Recombinant (His)	Human	E. coli
	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to fo...
TMPJ-00771	TGF beta 1 Protein, Mouse/Rat, Recombinant	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differen...
TMPH-03156	Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the fun...
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Complement factor I Protein, Mouse, Recombinant (His)

TMPK-01023

Species: Mouse

Expression System: HEK293 Cells

Complement factor I Protein, Human, Recombinant (His)

TMPK-00776

Species: Human

Expression System: HEK293 Cells

Complement factor I Protein, Rat, Recombinant (His & Myc)

TMPH-03273

Species: Rat

Expression System: Baculovirus Insect Cells

IGF1/IGF-I Protein, Human, Recombinant

TMPY-06982

Species: Human

Expression System: E. coli

IGF1/IGF-I Protein, Mouse, Recombinant

TMPY-04878

Species: Mouse

Expression System: P. pastoris (Yeast)

IGF1R/CD221 Protein, Human, Recombinant (His)

TMPY-00834

Species: Human

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)

TMPY-02535

Species: Mouse

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)

TMPY-01459

Species: Human

Expression System: HEK293 Cells

EIF4A1 Protein, Human, Recombinant (His & Myc)

TMPH-01306

Species: Human

Expression System: E. coli

LR3-IGF-1 Protein, Mouse, Recombinant (His)

TMPJ-00781

Species: Mouse

Expression System: E. coli

TNF R1 Protein, Mouse, Recombinant

TMPJ-00280

Species: Mouse

Expression System: E. coli

IGF1 LR3 Protein, Human, Recombinant

TMPY-04942

Species: Human

Expression System: P. pastoris (Yeast)

IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00020

Species: Human

Expression System: HEK293 Cells

4EBP1 Protein, Human, Recombinant (His)

TMPY-01769

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His & GST)

TMPY-04360

Species: Human

Expression System: Baculovirus Insect Cells

IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06905

Species: Human

Expression System: HEK293 Cells

EIF3I Protein, Rat, Recombinant (His)

TMPH-03288

Species: Rat

Expression System: Baculovirus Insect Cells

EIF3I Protein, Rat, Recombinant (E. coli, His)

TMPH-03289

Species: Rat

Expression System: E. coli

ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)

TMPY-04366

Species: Human

Expression System: Baculovirus Insect Cells

ALK-5 Protein, Human, Recombinant (hFc)

TMPY-05771

Species: Human

Expression System: HEK293 Cells

ALK-5 Protein, Human, Recombinant (His & hFc)

TMPY-01358

Species: Human

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)

TMPY-01639

Species: Mouse

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)

TMPY-05475

Species: Human

Expression System: HEK293 Cells

TGF beta 2 Protein, Mouse/Rat, Recombinant

TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

TGFBI Protein, Human, Recombinant (His)

TMPY-01009

Species: Human

Expression System: HEK293 Cells

Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)

TMPY-02185

Species: Human

Expression System: HEK293 Cells

LTBR Protein, Mouse, Recombinant (hFc)

TMPJ-00994

Species: Mouse

Expression System: HEK293 Cells

IGF1/IGF-I Protein, Human, Recombinant (hFc)

TMPK-00083

Species: Human

Expression System: HEK293 Cells

CD46 Protein, Canine, Recombinant (His)

TMPK-00570

Species: Canine

Expression System: HEK293 Cells

Nucleolar transcription factor 1 Protein, Human, Recombinant (Cell-Free, His & SUMO)

TMPH-01798

Species: Human

Expression System: E. coli

HER2/ErbB2 Protein, Human, Recombinant (His & Avi)

TMPK-00428

Species: Human

Expression System: HEK293 Cells

Nucleolar transcription factor 1 Protein, Human, Recombinant (E. coli, His & SUMO)

TMPH-01799

Species: Human

Expression System: E. coli

SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01702

Species: Human

Expression System: E. coli

IGFBP-7 Protein, Mouse, Recombinant (hFc)

TMPK-01027

Species: Mouse

Expression System: HEK293 Cells

FLT3LG Protein, Mouse, Recombinant (His)

TMPJ-00123

Species: Mouse

Expression System: HEK293 Cells

CD46 Protein, Cynomolgus, Recombinant (His)

TMPK-00532

Species: Cynomolgus

Expression System: HEK293 Cells

LTBR Protein, Human, Recombinant (His)

TMPJ-00274

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (hFc)

TMPK-01371

Species: Human

Expression System: HEK293 Cells

EIF1AX Protein, Human, Recombinant (His)

TMPJ-00973

Species: Human

Expression System: E. coli

Vasorin Protein, Human, Recombinant (His)

TMPJ-00572

Species: Human

Expression System: HEK293 Cells

CR1L Protein, Mouse, Recombinant (His)

TMPH-02606

Species: Mouse

Expression System: E. coli

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

TMPY-01710

Species: Human

Expression System: E. coli

DPEP1 Protein, Human, Recombinant (His)

TMPY-03329

Species: Human

Expression System: HEK293 Cells

ACVR2A Protein, Human, Recombinant (hFc & His)

TMPJ-00315

Species: Human

Expression System: HEK293 Cells

ACVR2B Protein, Human, Recombinant (hFc & His)

TMPJ-00314

Species: Human

Expression System: HEK293 Cells

F13A Protein, Human, Recombinant (His)

TMPJ-00535

Species: Human

Expression System: HEK293 Cells

STAT2 Protein, Human, Recombinant (His)

TMPU-00003

Species: Human

Expression System: E. coli

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

TGF beta 1 Protein, Mouse/Rat, Recombinant

TMPJ-00771

Species: Mouse,Rat

Expression System: HEK293 Cells

Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)

TMPH-03156

Species: Porphyromonas gingivalis

Expression System: E. coli

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Cat No.	Product Name
L4100	TGF-beta/Smad Compound Library		184 compounds
	A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;

Libraries

TGF-beta/Smad Compound Library

L4100

Compounds: 184